CORDIS Project
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This project investigates the liver stage of Plasmodium parasites, which cause malaria, to identify potential vaccine targets. By analyzing genes regulated by a key developmental factor, the project aims to enhance understanding of parasite differentiation and improve malaria prevention strategies.
Infection of the liver by Plasmodium parasites, the causative agents of malaria, is an essential and clinically silent phase that constitutes an ideal target for anti-malarial prophylactic approaches such as vaccines.
After inoculation in the skin by a mosquito, Plasmodium sporozoites migrate to the liver and invade hepatocytes, where they differentiate into liver stages and thousands of pathogenic merozoites.
Liver stage-infected hepatocytes are potential targets for protective CD8 T cells elic…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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