CORDIS Project
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The STARFISH DNA project aims to develop new compounds that stabilize three-way DNA junctions, creating targeted DNA damage in cancer cells. This approach seeks to enhance cancer treatment by using these compounds alone or in combination with existing therapies to improve efficacy.
Cancer is a generic term for a group of diseases characterized by the uncontrolled growth and spread of cells with abnormal proliferating activity.
Most of the anticancer drugs currently used in the clinic trigger irreversible DNA damages and thus, promote replicative stress.
As an alternative of irreversible DNA strand breaks, the non-covalent small-molecule stabilization of unusual, non-B DNA structures has emerged as a promising way to create DNA damages.
One of such non B-DNA structures is a…
UNIVERSITE DIJON BOURGOGNE
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