CORDIS Project
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This project explores the mechanisms of protein misfolding and amyloid formation, which are linked to diseases like Alzheimer's. By studying specific proteins across different species, it seeks to uncover evolutionary insights and develop strategies to prevent amyloid-related diseases.
Protein misfolding and aggregation into amyloid fibrils is a hallmark of serious diseases such as Alzheimer´s, Familial Amyloidotic Polyneuropathy (FAP) and atherosclerosis.
Amyloid fibrils can also be biologically functional.
Bacterial and fungal amyloids are proposed to form a prominent protein fold early in evolution.
It is unclear why many different proteins, which often assume stable functional quaternary structure under normal conditions, can convert into a common β-sheet rich amyloid aggr…
CENTRO DE CIENCIAS DO MAR DO ALGARVE
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