CORDIS Project
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This project investigates how Staphylococcus aureus adapts to survive in hostile environments within the host. It focuses on the role of specific lipid changes in the bacteria's membrane composition during immune responses, aiming to uncover new targets for treatments against these infections.
Staphylococcus aureus infections are associated with significant morbidity and mortality in healthcare and community settings.
Inside the host, invading S. aureus is challenged by host innate immune defenses that include professional phagocytes and an arsenal of secreted antimicrobials.
Long term persistence of S. aureus may be due to adoption of quiescent physical and metabolic states, such as biofilms, endocardial vegetations, and small colony variants.
The metabolic changes needed for adaptat…
KEMIJSKI INSTITUT
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