CORDIS Project
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This project focuses on understanding and regulating the deadenylation process of mRNA, which is crucial for mRNA stability and gene expression. By designing specific peptide analogues, the project aims to inhibit the CCR4-NOT complex, a key regulator in this process, with potential therapeutic applications in cancer t…
RNA has gained significant attention in the past few decades due to its evolutionary role in gene regulations.
In the regulation process RNA seldom works as an individual entity rather associated with several protein-protein complexes (PPCs) and those complexes play a key role in mRNA maturation.
Typically, mRNA undergoes different post-transcriptional modifications and deadenylation is one of those post-transcriptional events in which shortening of the poly(A) tail at the 3 end of mRNA occurs a…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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