CORDIS Project
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This project investigates how myofibroblasts and cancer-associated fibroblasts influence epithelial cell functions in the gut. By examining their mechanical properties and interactions, the research aims to understand their roles in both healthy and cancerous conditions.
There has been tremendous progress in understanding the importance of the microenvironment and its chemical signals for homeostasis of stem cell niche in the intestine and for tumor invasion and metastasis formation in many different tissues.
However, the way stromal cells such as myofibroblasts or cancer-associated fibroblasts (CAFs) use mechanical forces to shape the extracellular matrix and consequently dictate the response of epithelial cells remains unexplored at the single-cell level mainl…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, Paris
Type: Research institute
Activity type: Research Organisations
SME: No
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