CORDIS Project
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This project investigates the role of specific proteins, particularly ACBD3 and PI4KB, in activating the STING pathway, which is crucial for immune responses against tumors and viral infections. It aims to uncover how these proteins influence STING activity and how RNA viruses may exploit this mechanism to evade immune…
The immune response to cytosolic DNA is crucial for preventing tumour formation and virus infection.
This response critically depends on the cGAS-STING pathway, which detects cytosolic self-DNA present in tumour cells and viral DNA. STING can also detect cytosolic self-DNA induced by upon RNA virus infections, and numerous RNA viruses have evolved strategies to disable STING.STING activation is a complex process that requires various post-translational modifications, leading to STING trafficking…
UNIVERSITEIT UTRECHT
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