CORDIS Project
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This project investigates the biosynthesis of phosphatidylinositol 4-phosphate, a critical molecule for intracellular processes and viral replication. The goal is to understand its structure and develop specific inhibitors that could serve as antiviral agents against viruses like Hepatitis C and SARS.
Phosphatidyl inositol phosphates (PIPs) are biosynthesized from phosphatidyl inositol (PI) by the action of PI kinase.
The phosphatidylinositol 4-phosphate (PI(4)P) is produced by the action of phosphatidylinositol 4-kinase (PI4K). PIPs are universal markers of intracellular membranes.
Their precise spatial and temporal resolution control enables various protein machineries to operate in the correct location at the exact time. PI(4)P is the single most abundant mono phosphoinositide and is the m…
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
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