CORDIS Project
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StarTicking investigates the development of the circadian timing system, focusing on how the master pacemaker in the brain matures during pregnancy. By studying both mice and human organoids, the project aims to understand how environmental factors influence this system and its implications for offspring behavior.
The 24-h (circadian) timing system develops during the perinatal period and rules our physiology later in life.
It has the essential task of anticipating daily recurring changes in the environment (day/night) to find the best time for each molecular and cellular process.
It is organised hierarchically, with a master pacemaker in the hypothalamic suprachiasmatic nucleus (SCN), which is able to perceive environmental light and tell the body what time is it.
Our modern 24/7 lifestyle favours a disr…
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