CORDIS Project
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This project investigates the mechanisms that trigger the START phase of cell division in budding yeast using advanced techniques like microfluidics and optogenetics. By analyzing single-cell data and applying dynamic perturbations, it aims to enhance understanding of cell cycle regulation, which may have implications…
Cells across all kingdoms of life have developed exquisite control mechanisms to achieve and maintain the balance between cell growth and division.
The decision to commit to cell division is a ubiquitous and essential process, whose dysregulation can dramatically affect cell viability in simple eukaryotes, while leading to tumorigenesis in mammalian cells.
In budding yeast, the short interval in late G1 where commitment to cell division is decided, is known as START.
Despite years of research, i…
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