CORDIS Project
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This project investigates the mechanisms of memory formation at the cellular level, focusing on the stabilization of short-term memories through specific protein interactions. It employs optogenetics to manipulate neuronal activity and test hypotheses related to memory consolidation.
It is shown that long-term potentiation (LTP) is the cellular basis of memory formation.
However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed.
Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP.According to Synaptic Tagging and Capture (STC…
AARHUS UNIVERSITET
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