CORDIS Project
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This project investigates the interaction between liver stellate cells and Kupffer cells to understand how these relationships influence liver fibrosis. By analyzing gene expression in paired and unpaired cells, the research aims to identify signals that keep stellate cells inactive, potentially leading to new treatmen…
Liver diseases are a global cause of mortality, accounting for two million deaths a year, of which half are attributed to liver fibrosis.
Activated stellate cells are the major source of excessive extracellular-matrix deposition that drives fibrosis.
The signals that convert quiescent stellate cells into pathogenic myofibroblasts remain largely unknown.
Spatial analysis from the Guilliams lab has recently revealed that each quiescent stellate cell is paired with a Kupffer cell (KC) in the steady…
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