CORDIS Project
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This project focuses on using human pluripotent stem cells to model heart arrhythmias for better understanding and treatment. It aims to identify genetic variants contributing to these conditions and improve patient-specific therapies through advanced gene-editing techniques.
Among the most significant conceptual changes in stem cell biology of the past decade has been the use of human pluripotent stem cells (hPSCs) for disease modelling and drug development rather than solely as therapeutics.
One area of major interest in this context is that of arrhythmic disorders of the heart.
Cardiac arrhythmias are a leading cause of death among young people, with inherited forms affecting as many as 1 in 2000.
Even more prevalent are acquired arrhythmias due to adverse respons…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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