CORDIS Project
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This project focuses on identifying and studying adult stem cells using genetic mouse models that express specific markers, particularly Lgr5. By analyzing these stem cells in various tissues, the research aims to understand their characteristics and roles in health and disease, with potential implications for cancer r…
Self-renewal and repair of tissues in adult mammals is fueled by rare tissue stem cells.
Identification and subsequent study of such adult stem cells depends strictly on the availability of molecular markers.
To date, a paucity of single definitive markers has complicated the study of the biology of these rare cells.
Our interest in the role of the Wnt pathway in intestinal homeostasis and cancer has led us to exhaustively define the Wnt target gene program shared between these two processes.
Wi…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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