CORDIS Project
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This project investigates the use of bone marrow stromal cells in treating ischemic stroke by analyzing their secretome in the cerebrospinal fluid. It aims to determine if a 'cell-free' secretome can replicate the beneficial effects of the cells, potentially leading to safer therapies for stroke recovery.
Bone marrow stromal cells (BMSCs) have been shown to be neuroprotective after experimental ischemic stroke when given systemically.
By this route of administration, however, over 99% of cells are trapped in lung, spleen and kidneys.
This off-target distribution of BMSCs may result in serious ectopic side-effects thereby making their use in humans questionable.The applicant’s previous work has demonstrated that transplantation of BMSCs to the cerebrospinal fluid compartment (CSFC) reduces post-is…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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