CORDIS Project
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This project investigates the immune mechanisms in stem cells that protect them from viral infections and transposable elements. By studying a specific protein, aviD, and its role in antiviral responses, the research aims to uncover new biological insights and potential therapeutic applications in cancer treatment.
Stem cells guard tissue integrity by renewing the pool of differentiated cells, and must therefore be shielded from threats such as transposable elements or viruses.
In that line, stem cells can largely resist viral infections, but they do so without deploying the antiviral pathways at play in differentiated cells.
So, what guards the guardians? I recently discovered a stem cell-specific immune pathway, driven by a protein termed aviD (antiviral Dicer), which mounts an antiviral RNA interference…
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