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The SteMiCCA project focuses on understanding and targeting the interactions between cancer stem cells and the tumor microenvironment in intrahepatic cholangiocarcinoma. By employing advanced in vitro and in vivo models, the project aims to uncover new therapeutic targets for this aggressive liver cancer.
Intrahepatic cholangiocarcinoma (iCCA) is the second primary malignancy of the liver with few therapeutic options, late diagnosis, chemotherapy resistance and dismal prognosis. iCCA incidence and mortality increased worldwide in the last decades, linked to the rise of risk factors including non-alcoholic steatohepatitis. iCCA is a highly heterogeneous tumor characterized by a complex and dynamic tumor microenvironment (TME) where stromal cells coexist with cancer and cancer stem cells (CSC).
CSC…
FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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