CORDIS Project
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This project examines the regulation of blood stem cells in the bone marrow and their relationship with the nervous system. It aims to uncover new therapeutic approaches for blood cancers by understanding the niche's role in stem cell maintenance.
Blood cells are produced in the bone marrow, which contains two distinct adult stem cell types: haematopoietic stem cells (HSCs), that generate all blood and immune cells, and mesenchymal stem cells (MSCs), thought to form the skeleton. HSCs traffic between bone marrow and circulation, what allows for life-saving clinical transplantation.
Our previous work has shown that HSC numbers in blood are regulated by the central pacemaker in the brain, which reaches bone marrow nestin+ MSCs through the n…
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