CORDIS Project
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This project investigates how cells repair DNA damage that blocks gene transcription by RNA polymerase II. It aims to understand the mechanisms of transcription-coupled repair and how cells restore transcription and resolve conflicts between transcription and DNA replication.
Bulky DNA lesions are a major obstacle during gene transcription by RNA polymerase II enzymes (RNAPII).
The stalling of RNAPII at DNA lesions triggers a genome-wide transcriptional arrest.
Transcription-coupled repair (TCR) is a specialized DNA repair pathway that selectively removes DNA lesions from actively transcribed genes to restore transcription.
Stalled RNAPII at DNA lesions forms a roadblock for advancing DNA replication forks resulting in toxic collisions.
The mechanisms that enable the…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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