CORDIS Project
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This project investigates the roles of two essential protein kinases, PknB and PknG, in Mycobacterium tuberculosis. It focuses on their regulation of primary metabolism, particularly in cell shape and nutrient processing, aiming to identify potential drug targets for tuberculosis treatment.
The genome of Mycobacterium tuberculosis contains 11 serine threonine protein kinases.
Amongst these PknA, PknB and PknG are essential for bacterial survival and/or virulence, and are considered potential drug targets.
This proposal aims to elucidate the functions of PknB and PknG, with particular focus on the regulation of primary metabolism.
PknB is reported to be involved in the control of cell-shape, whereas PknG might function as a regulator of metabolism or as a virulence protein secreted…
UNIVERSITY OF LEICESTER
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