CORDIS Project
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This project aims to enhance cardiac regeneration by exploring the Notch signaling pathway and its interaction with the extracellular matrix. It involves creating a 3D model of cardiac tissue to study stem cell differentiation and develop technology for controlled modulation of Notch signaling.
Heart failure is a major health issue and a cause of death and disability.
The endogenous regenerative capacity of the heart is too weak to recover from damage and instead the heart repairs damage by synthesis of a scar tissue leading to functional deterioration.
To improve cardiac regeneration, stem cell therapies and material-based approaches have been developed but up till now with limited success as we still lack detailed knowledge of and the functional technology to guide the regenerative p…
TECHNISCHE UNIVERSITEIT EINDHOVEN
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