CORDIS Project
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This project aims to develop a therapy using neurotrophin 3 to enhance recovery of arm and hand function in stroke-affected rats. It focuses on optimizing treatment parameters to prepare for a clinical trial in humans, while investigating the underlying mechanisms of brain plasticity.
Stroke disables millions worldwide and costs the EU €38 billion each year.
Excitingly, my team has identified a clinically-feasible therapy for stroke which reverses disability in rats when given in a clinically-relevant time frame.
Specifically, we have shown that the human growth factor neurotrophin 3 (NT3) promotes locomotor recovery and reverses sensory neglect in adult rats when infused into disabled arm muscles, starting 24 hours after stroke.
Importantly, Phase II clinical trials have sho…
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