CORDIS Project
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This project studies how the stiffness of the extracellular matrix affects blood and lymph vessel formation. By analyzing gene expression in endothelial cells, it aims to identify key regulatory mechanisms involved in angiogenesis and lymphangiogenesis, with potential implications for treating edema.
Endothelial cells (ECs) recognize and respond to mechanical forces through their cell-cell and cell-matrix adhesions and translate physical stimuli into biological responses in a process called mechanotransduction.
The composition and mechanical properties of the extracellular matrix (ECM) differ across the vascular tree, in its surrounding tissues and in development and diseases, such as edema formation. I have recently shown for the first time that ECM stiffness fundamentally controls lymphang…
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
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