CORDIS Project
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This project focuses on understanding how Legionella pneumophila, the bacterium causing Legionnaires' disease, manipulates host cells. It employs structural biology to characterize the bacterium's secretion system and its effectors, aiming to inform drug design against infections.
Legionella pneumophila is the causative agent of a severe form of pneumonia known as Legionnaires’ disease.
Legionella utilizes a type IV secretion system, encoded by the dot/icm gene cluster, to secrete circa 300 effectors that highjack host cellular function to allow the bacterium to live intracellularly inside macrophages.
Although the molecular basis of effector function has been elucidated for a small number of effectors, there remain a large number of effectors for which no function has be…
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