CORDIS Project
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This project investigates the molecular mechanisms regulating cell division, focusing on the role of the Ska complex in stabilizing attachments between kinetochores and microtubules. The research aims to understand how this complex interacts with other proteins to ensure accurate chromosome segregation.
Cell division, the accurate transfer of genetic information from one cell generation to the next is the molecular basis of life. A number of mitotic molecular machines involving an extensive network of protein-protein interactions are implicated in regulating cell division.Kinetochore (KT) - Microtubule (MT) attachments are central to the accurate chromosome segregation.
Among the KT associated proteins, set of proteins called KMN network (KNL-1-Ndc80-Mis12) provides direct MT interactions.
Prot…
THE UNIVERSITY OF EDINBURGH
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