CORDIS Project
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This project aims to determine the three-dimensional structure of mitochondrial ribosomes from bovine heart mitochondria. Understanding their structure is crucial for insights into protein synthesis and the effects of antibiotics on mitochondrial function.
The ribosome is a large ribonucleoprotein particle which translates mRNA to proteins through a sophisticated process that combines high speed and accuracy.
It thus plays a central role in protein biosynthesis, translation, which is a fundamental and essential process in all cells.
Mitochondria contain a translational system that is distinct from that of the cell cytoplasm.
Mitochondrial ribosomes have remarkable divergence from those of bacteria and the eukaryotic cytoplasm.
Most of the mitochon…
MEDICAL RESEARCH COUNCIL
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