CORDIS Project
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The project focuses on understanding the structure and function of P-type ATPases, essential membrane pumps in cells. By studying the plasma-membrane Ca2+-ATPase and Na+,K+-ATPases, it aims to elucidate their regulatory mechanisms and interactions within native membranes using advanced imaging techniques.
P-type ATPases are cell-membrane pumps that are of fundamental importance in eukaryotes.
The ion gradients created by Ca2+-ATPases or Na+,K+-ATPases are involved in signalling, maintaining the membrane potential as well as secondary active transport.
Despite the recent progress in membrane protein crystallography, the lack of detailed structural information currently prevents a better understanding of function and specificity of cation pumps.
One specific aim of this proposed research is to dete…
AARHUS UNIVERSITET
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