CORDIS Project
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The project focuses on understanding the fusion mechanism of influenza virus membranes, specifically the role of the haemagglutinin protein. It aims to determine the structure of this protein to aid in developing effective antiviral therapies.
The fusion of biological membranes underlies basic cellular processes of vesicle transport as well as the infectivity of enveloped viruses.
The haemagglutinin (HA) glycoprotein of influenza viruses mediates fusion between viral and cellular membranes at the pH of the endosome to deliver the viral genome into the cytosol.
Despite its high surface variability, its fusion machinery is conserved among HA subtypes and is a prime target for broadly neutralizing antibodies. HA consists of the receptor-…
THE FRANCIS CRICK INSTITUTE LIMITED
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United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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