CORDIS Project
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This research focuses on the virulence mechanisms of Gram-positive Enterococci, particularly the role of adhesion proteins in infection and antibiotic resistance. The study aims to identify host interactions that facilitate bacterial colonization and biofilm formation.
Gram-positive Enterococci account for a significant fraction of hospital-acquired infections but are often difficult to treat due to their proficiency in colonizing damaged host tissues, forming biofilms, and acquiring and spreading antimicrobial resistance (AMR).
These AMR genes and additional virulence factors are often disseminated among the bacterial population via conjugation, the horizontal transfer of mobile genetic elements between cells in physical contact.
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