CORDIS Project
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This project focuses on developing Proteolysis Targeting Chimeras (PROTACs), which are small molecules designed to degrade specific proteins linked to diseases. By enhancing the design process through virtual screening and structure-based methods, the project aims to create effective PROTACs for previously undruggable…
Proteolysis Targeting Chimeras (PROTACs) are small molecules that induce the degradation of target proteins of interest and have shown considerable promise as novel therapeutic agents. PROTACs are heterobifunctional compounds containing one moiety that binds to the target protein of interest and one that binds to an E3 ubiquitin ligase.
Recruitment of the E3 ligase leads to ubiquitination and subsequent degradation of the target by the proteasome.
The design of PROTACs largely remains an empiri…
UNIVERSITY OF DUNDEE
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