CORDIS Project
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This project focuses on Mycobacterium abscessus, a drug-resistant bacterium causing infections. It aims to investigate the structure and function of a specific secretion system that is crucial for the bacterium's survival within host cells, providing insights for potential therapeutic targets.
Mycobacterium abscessus (Mab) is an opportunistic-multidrug-resistant non-tuberculous mycobacteria responsible for multiple clinically-acquired infections both pulmonary and extrapulmonary.
Unlike many rapidly growing mycobacteria (RGM), Mab is able to survive and multiply within macrophages, similar to slow growing mycobacteria (SGM) such as M. tuberculosis (Mtb).
In Mtb, five T7SS (ESX-1-5) have been identified and shown to be essential for intracellular survival (ESX-1), virulence (ESX-1 and…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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