CORDIS Project
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This project focuses on understanding the structure and activation mechanisms of the U4/U6 small nuclear ribonucleoprotein complex, which is essential for mRNA splicing. Techniques such as X-ray crystallography and mass spectrometry will be employed to explore the biochemical properties and interactions within this com…
The spliceosome is a large RNA–protein assembly that catalyzes the removal of introns from mRNA precursors (pre-mRNA) and the splicing of coding exons to produce mature mRNAs.
Four small nuclear ribonucleoprotein particles (U1, U2, U5 and U4/U6 snRNPs) assemble onto pre-mRNA substrates together with non-snRNP proteins to form the spliceosome.
After binding of the U1 snRNP and the U2 snRNP to the 5’ splice site and the branch point sequence within the intron, a pre-assembled U4/U6.U5 tri-snRNP…
MEDICAL RESEARCH COUNCIL
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