CORDIS Project
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This project investigates the molecular mechanisms of telomere length maintenance in germ cells, focusing on the role of specific DNA-binding complexes during meiosis. By understanding how telomeres are regulated, the research aims to shed light on aging, cancer development, and genetic inheritance.
The length of telomeric DNA is a critical determinant factor for aging and cancer development.
In germ cells, the activation of a telomerase-dependent telomere-lengthening pathway is thought to be important in order to maintain telomeric DNA across generations, but the molecular mechanisms involved in this pathway, i.e: how and when telomerase is activated in germ cells, are largely unknown.A DNA-binding protein complex called shelterin constitutively binds telomeric DNA.
However, my recent stud…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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