CORDIS Project
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This project focuses on understanding the role of gamma-secretase in the production of amyloid beta-peptide, which is linked to Alzheimer's disease. It aims to investigate how aging affects gamma-secretase activity and its implications for amyloid accumulation in the brain, shedding light on the disease's development.
Alzheimer’s disease (AD) is the most common form of dementia.
The main hallmark of AD is presence of the extraneuronal senile plaques composed of amyloid beta-peptide (Aβ). Aβ is produced when a transmembrane glycoprotein called Amyloid Precursor Protein (APP) is consecutively cleaved by two proteases: the γ-secretase and the β-secretase. γ-Secretase can render distinct length isoforms of Aβ, with Aβ40 and Aβ42 most studied in the context of AD pathology.
Aging is the single most important risk…
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