CORDIS Project
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This project investigates the organization of cellular structures involved in skeletal muscle cell differentiation, focusing on the secretory pathway's role. It aims to understand how specialized domains like the sarcoplasmic reticulum and Golgi complex interact during this process.
Skeletal muscle (SKM) cell differentiation and remodeling require synthesis and transport of an enormous amount of proteins to build up its’ highly specialized structures, likely entailing an important involvement of the secretory pathway.
The sarcoplasmic reticulum (SR) of SKM cells is a specialized form of endoplasmic reticulum (ER), formed by a complex network of tubules and cisternae sharing a common lumen, that can be subdivided in the junctional SR, responsible for calcium release, and the…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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