CORDIS Project
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This project investigates the role of inflammatory mediators, specifically chemokines and microglial cells, in age-related macular degeneration (AMD). It aims to identify genetic factors and molecular pathways that contribute to AMD progression and to explore new therapeutic strategies to mitigate vision loss.
Age-related macular degeneration (AMD) is the leading cause of vision loss in the Europe.
New anti-angiogenic therapies of AMD do not treat the neurodegenerative aspect of AMD.
Recent evidence suggests an implication of inflammatory mediators in AMD.
We have focused our interest on the potential role of chemokines (Ch) and microglial cells (MC) in this condition.
Our data concerning the chemokine receptor (CR) CX3CR1, indicates that (i) CR are expressed on MCs in human and mice; (ii) CR-positive…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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