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The SuccHSC project investigates how succinate, an inflammation-related molecule, influences the transformation of hematopoietic stem cells into leukemic stem cells in acute myeloid leukemia. By examining epigenetic changes and gene expression, the project aims to uncover mechanisms behind leukemia onset and relapse, p…
In life, no matter how small, changes can have huge impact on its quality.
For hematopoietic stem cells (HSC), similar can happen.
Through minor shifts, from normal to pre-leukemic and finally leukemic phenotype, generation of leukemic stem cells (LSC) results in overt malignancy, such is acute myeloid leukemia (AML).
Life quality of AML patients is severely impaired, even in “disease-free” state after the treatment. AML chemotherapy and stem cell transplant offers 5-year survival to only 20% of…
UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
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