CORDIS Project
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This project investigates the role of O-GlcNAc modification in regulating intracellular proteins, focusing on its implications in diseases like cancer and diabetes. It aims to explore how certain bacteria utilize this modification as a virulence factor, potentially leading to new therapeutic strategies against bacteria…
O-GlcNAc modification of specific serines/threonines on intracellular proteins in higher eukaryotes has been shown to directly regulate important processes such as the cell cycle, insulin sensitivity and transcription.
This dynamic modification, which shows interplay with protein phosphorylation, is regulated by two counteracting proteins, which catalyse transfer of GlcNAc from UDP-GlcNAc to specific serines/threonines on protein substrates (by O-GlcNAc transferase) and the subsequent hydrolysis…
UNIVERSITY OF DUNDEE
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