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The SUGARSmart project aims to enhance the design of antibodies that recognize glycans, which are crucial for diagnosing diseases. By utilizing molecular modeling and experimental validation, it seeks to create a framework for engineering glycan-specific antibodies for improved diagnostic and therapeutic applications.
The development of new approaches to explore the diverse role of glycans in normal and physio- pathological conditions of the cell is a major challenge.
Our previous research recognized roles of anti-glycan recognition molecules (lectins and antibodies) in the diagnosis of diseases like cancer, immunity, and hyperacute rejection upon bioprosthetic transplantation etc.
However, because of the structural complexity, well-established approaches for developing glycan-based therapeutics are limited.T…
UNIVERSITY OF GALWAY
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