CORDIS Project
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This project aims to understand the role of protein persulfidation in cellular processes and its implications for aging and diseases. By investigating the dynamics of this post-translational modification, the research seeks to identify potential therapeutic targets for improving health and longevity.
Life originally emerged and flourished in hydrogen sulfide (H2S)-rich environment and literature published in the past decade started to recognize that H2S is a mediator of many physiological and pathological processes.
Exposure to H2S can put animals into suspended animation-like state while the lifespan extensions by the dietary restriction are caused by H2S accumulation.
Disturbances in its production are linked to the development of neurodegenerative diseases and cancer, among many others. A…
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