CORDIS Project
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This project investigates the role of sulfur in the pathogenicity of Aspergillus fumigatus, a major lung pathogen. It aims to identify sulfur sources during infection and develop novel antifungal therapies based on these findings.
Aspergillus fumigatus, the major mould pathogen of human lungs, is responsible for > 2 million illnesses per annum in Europe . I have discovered that sulphur is an essential host-derived element during A. fumigatus infection .
This finding is novel, and highly exploitable as a) Synthesis of the sulphur-containing molecule methionine appears to be essential for viability of A. fumigatus b) Regulation of sulphur assimilation is essential for A. fumigatus virulence and c) The foremost candidate sul…
THE UNIVERSITY OF MANCHESTER
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