CORDIS Project
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The project focuses on studying proteins with broad specificity, particularly cytosolic sulfotransferases and proliferating cellular nuclear antigen. It aims to enhance understanding of their functions through directed evolution and chemical genetic techniques.
Proteins that exhibit broad specificity play important roles in different biological processes.
These proteins include enzymes that catalyse the chemical transformation of many different substrates and proteins that bind to multiple protein partners.
We propose to develop and apply novel directed evolution and chemical genetic methodologies for the study of proteins that exhibit broad specificity, with focus on cytosolic sulfotransferases (SULTs), which detoxify a broad range of xeno- and endobi…
BEN-GURION UNIVERSITY OF THE NEGEV
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