CORDIS Project
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This project investigates how specific proteins and chromatin structures maintain cell identity and how these mechanisms can be disrupted in diseases. The research aims to uncover the role of sumoylation in regulating cell fate transitions, with implications for regenerative medicine and cancer treatment.
The maintenance of cell identity and how it is subverted in disease are central questions in biology and medicine.
The interplay between transcription factor and chromatin configurations plays a key role in maintaining cellular identity, yet how this interplay is regulated is poorly understood.
Notably, the existence of possible general mechanisms underlying different cell-state specifications remains to be determined.
We have recently uncovered evidence that sumoylation, which deposits a chroma…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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