CORDIS Project
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This project investigates the biogenesis of small nucleolar RNA-protein complexes (snoRNPs) and their regulation through SUMOylation. It aims to identify the SUMO E3 ligase ZNHIT6 and its role in RNA metabolism using advanced techniques like CRISPR/Cas and mass spectrometry.
It is widely accepted that eukaryotic cells contain large populations of small nucleolar RNA-protein complexes (snoRNPs), which mediate the modification of rRNA nucleotides and facilitate cleavage of rRNA precursors.
Thus, they may control general protein translation by regulating the level and function of ribosomes.
It is currently thought that understanding the process of snoRNP biogenesis will provide the knowledge indispensable to determine their exact function and means of regulation.
Altho…
UNIVERSITY OF DUNDEE
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