CORDIS Project
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This project aims to develop a novel method for analyzing the size and structure of α-synuclein oligomers in human cerebral spinal fluid. By utilizing advanced spectroscopy and single-molecule fluorescence techniques, it seeks to differentiate oligomer properties between healthy individuals and Parkinson’s disease pati…
Parkinson’s disease is the most common movement disorder caused by neurodegeneration, for which there is no cure, no way of modifying the disease and no clinically accepted diagnostic tool.
In the brain, the intrinsically disordered monomeric protein α-synuclein misfolds, aggregates and accumulates to form proteinaceous inclusions termed Lewy bodies.
This process forms ‘oligomers’, intermediates in the aggregation pathway that are strongly implicated in the cellular toxicity that causes the dise…
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THE BOARD OF REGENTS OF THE UNIVERSITY OF WISCONSIN SYSTEM
United States, Madison Wi
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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