CORDIS Project
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This project aims to eradicate HIV by developing a new strategy called 'lock-in and apoptosis.' It focuses on creating derivatives of a compound called L-HIPPO to effectively induce cell death in HIV-infected cells, overcoming limitations of existing treatments.
Main challenge of fighting with the HIV is to eliminate the latent viral reservoir from the body.
This reservoir is resistant to antiretroviral drug therapy and can cause viral rebound if the treatment is stopped.
The removal of the reservoir enables HIV eradication, is urgently desired in HIV-AIDS research.
For this purpose, a strategy called “kick and kill” was proposed, based on the hypothesis that activation of latent HIV (“kick”) leads to cell death (“kill”) by physical damage and/or immune…
IZMIR KATIP CELEBI UNIVERSITESI
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