CORDIS Project
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This project explores the mechanisms of collective cell migration, particularly in the context of embryonic development and cancer metastasis. By studying neural crest cells, it aims to uncover how cells communicate and coordinate their movements during migration, which is crucial for understanding cancer invasion.
Collective chemotaxis (CCT) is a fundamental process for embryonic development and cancer metastasis, where groups of cells collectively migrate in response to a chemoattractive signal.
While single cell migration depends on polarised actomyosin mechanotransduction and signalling cascades within the same cell, in CCT these functions are shared between different cells to achieve a coordinated, ‘‘supracellular’’ translocation.
The molecular mechanisms underlying coordination and cell-cell communic…
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