CORDIS Project
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This project aims to explore the molecular mechanisms that maintain protein balance in neurons and protect against neurodegenerative diseases. By focusing on Ribosome-associated Quality Control, it seeks to understand how defects in this process contribute to cellular dysfunction.
Proteostasis is a dynamic network integrating protein biogenesis, folding, trafficking, and degradation to build a functional proteome.
Disrupted proteostasis resulting the accumulation and aggregation of aberrant proteins in neurons is a hallmark of neurodegenerative diseases.
This project’s overall goal is to uncover molecular mechanisms that maintain proteostasis and protect against neurodegeneration, by taking a fresh look at these processes through the lens of Ribosome-associated Quality Co…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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