CORDIS Project
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This project explores the mechanisms of neurotransmitter transport in synaptic vesicles, focusing on how these vesicles fill with neurotransmitters like glutamate and GABA. It employs biochemical techniques to study the transporters involved and aims to enhance our understanding of synaptic function.
SummaryIn presynaptic nerve endings, neurotransmitters are stored in synaptic vesicles (SVs) before they are released by exocytosis. SVs contain specific transporters that sequester and concentrate transmitters from cytoplasmic pools.
All known vesicular transporters belong to the solute carrier (SLC) superfamily of proteins.
They draw the energy for transport from an electrochemical proton gradient created by a V-ATPase across the vesicle membrane.
However, despite recent progress it is still l…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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