CORDIS Project
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This project proposes to investigate extended glycosylation, a type of protein modification, in mammalian cell nuclei. By exploring its presence, biosynthesis, and function, the research aims to expand our understanding of glycosylation's role in cellular processes and its implications in diseases.
Glycosylation is the most common post-translational modification (PTM), decorating two thirds of secreted human proteins.
Often dysregulated in disease, the specific attached glycan influences folding and function.
Extended glycosylation is supposed to exclusively occur in the secretory pathway. I propose that this model needs to be revised.
My preliminary results—both computational and experimental—question this long-standing dogma and hint at a new kind of PTM: extended glycosylation in mammal…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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